ÂéĥıAV

Description

Our laboratory has pioneered a chemical synthesis approach that produces a class of compounds previously unknown in the scientific literature. These molecules feature a reactive functionality that enables them to bind covalently and irreversibly to protein targets. While permanent protein modification may seem counterintuitive, such covalent interactions are increasingly exploited in drug discovery to achieve highly selective and potent therapeutic effects. Drugs like ibrutinib and sotorasib exemplify the clinical success of this approach, demonstrating how covalent binding can minimize unintended interactions and enhance efficacy. Evaluating our novel compounds in head and neck squamous cell carcinoma cell models revealed promising results: several molecules effectively suppressed tumor cell growth without causing measurable harm to healthy cells. These findings position our compounds as compelling candidates for the development of next-generation covalent therapeutics.

Description

The objective of this project is to develop an implementation toolkit that supports an NSF CRII research effort studying how initial node knowledge affects the round complexity and message complexity of distributed graph algorithms�˘â‚Ĵ”both for constructing solutions and verifying them. Goal: Build a lightweight, well-documented software toolkit for simulating synchronous distributed algorithms under different assumptions (e.g., CONGEST vs. LOCAL, and varying radius neighborhood knowledge). The toolkit will enable reproducible experiments on core graph problems such as: approximate BFS / BFS-like tree construction, single-source shortest paths, vertex coloring, maximal independent set and maximal matching. Interested applicants should email matn@augusta.edu with an attached CV and academic grade report(s)/transcript. All applications will be reviewed, but we may not be able to respond to every applicant. Only shortlisted candidates will receive a reply.

Description

Let's Jam: A Community Music Method is a novel music learning text in development through the music department of AU. Method book authors are looking for assistance with cultural artifact digital transfer, archival activities, and pilot testing. Student researchers will gain experience in educational arts publishing, digital resource management, and music pedagogy.

Description

The mathematical construction of a category comprises a web of abstract entities (called objects) and abstract relations between them (called arrows or morphisms). Higher category theory extends this picture with the introduction of higher-order relations, in the form of 2-arrows, 3-arrows, etc. These higher arrows are required to satisfy so-called coherence conditions that control how the higher category holds together. The choice of strictness of these conditions results in distinct structures and behavior. In this way, coherence is at the heart of higher category theory. The aim of this project is to identify minimal examples of 2-categories that clearly exhibit these variations in behavior.

Description

Summer 2026 will be the 150th anniversary of the Hamburg Massacre just across the river. Student will help write the script and record a multi-episode, narrative podcast telling the story of what happened in Hamburg. Student may also assist in creating a website to further disseminate information to the public about the events and more general events related to Reconstruction in ÂéĥıAV. This will utilize primary sources.

Description

Project 3: Machine learning, which is part of artificial intelligence, has become an invaluable tool to manipulate, analyze, predict, and reveal trends and associations hidden within big data. In this project students will explore the cross-cutting applications of quantum magnetism and machine learning applications to predict material properties. This work will utilize ÂéĥıAV' supercomputer

Description

Project 2: Magnetism is driven by the presence of electronic spin. Magnetic materials and magnetic phenomena (where magnetism is found) form the backbone of our data storage technology (e.g., computer hard drive). In this project students will use a combination of Monte Carlo and state of the art micromagnetic computer simulation techniques to investigate spin dynamics of novel magnetic materials. This work will utilize ÂéĥıAV' supercomputer

Description

Project 1: Quantum materials software packages such as Quantum Espresso and VASP are an invaluable tool to explore materials science. In this project students will utilize the quantum materials software (Quantum Espresso or VASP) to compute electronic structure and properties. Students will perform first principles calculations that will be utilized to explain experimental data. The work will be performed in close collaboration with experimentalists. This work will utilize ÂéĥıAV' supercomputer

Description

The pervasive contamination of water sources by toxic heavy metals poses a critical threat to ecosystem and human health. Conventional chemical chelators like EDTA, while effective, are environmentally persistent pollutants themselves, creating secondary waste streams. Algae species, including cyanobacteria, may offer a promising, sustainable alternative for bioremediation by leveraging natural biosorption processes. This research project will investigate the extent of nickel and zinc tolerance and accumulation in Spirulina major, a saltwater species found in both wastewater and local estuaries. This study will incorporate a multifactorial experiment with controls and experimental nickel and zinc treatments, using a hydroponic system under 1200-watt full-spectrum lights. If metal tolerance and accumulation are higher in metal solutions, this could indicate potential for algal bioremediation of some heavy metals in an estuarine system.

Description

This study examines how undergraduate students at ÂéĥıAV make decisions about pursuing math-intensive STEM majors (e.g., engineering, physics, computer science) compared to less-math-intensive STEM majors (e.g., biology, life sciences). Despite decades of efforts to broaden participation in STEM, disparities persist across gender, race/ethnicity, and socioeconomic status, with underrepresented groups less likely to enter or persist in math-intensive pathways that typically yield higher earnings and prestige. The project employs a mixed-methods design. Quantitative analyses of de-identified institutional data will identify patterns of enrollment, persistence, major switching, gateway course outcomes (e.g., calculus/physics sequences), and time-to-major declaration across student subgroups. Qualitative interviews with a purposive sample of AU students will then explore the mechanisms behind these patterns, with particular attention to science capital, hi

Description

The purpose of this investigation is to assess and monitor the impacts of human-made estuarine cuts on the salt marsh community in the Satilla River Estuary (SRE) before and after cut closures by the US Army Corps of Engineers. Healthy estuaries protect productive coastlines and support diverse ecosystems through the provision of migratory routes and nursery areas for many ecologically and economically important fish and invertebrate species. The salt marsh is a key foundation for this ecosystem and serves one part of a multifaceted approach focusing on vegetative and substrate dynamics at four locations adjacent and downstream of Noyes Cut in the SRE. Plant species diversity, density, and growth parameters have been collected since June 2014 at all locations: Todd Creek (reference), Parsons Creek, Piney Bluff Node, and Noyes Cut. With recent closures to Dynamite and Old River Run Cuts, some initial changes are being observed in plant communities.

Description

We will be sampling aquatic plants from Phinizy Nature Center for the presence of mercury. We are evaluating if wetland plants uptake mercury from the soil and if so, where is the mercury stored (roots, stems, leave, seeds). We will harvest and dry plants and send samples off for mercury analysis.

Description

This study examines how LGBTQ consumers respond to product designs at LGBTQ-supportive sporting events, focusing on explicit vs. subtle designs, consistent vs. temporary advocacy, and internalized sexual stigma (ISS). Drawing on signaling theory and self-verification theory, it predicts explicit designs with consistent advocacy will be seen as more authentic and sociable, while higher ISS may drive preference for subtle designs. Attitude toward LGBTQ people is expected to moderate links between authenticity, sociability, and purchase/wear intentions. Two 2�ƒâ€”2 experiments will use hypothetical and real Pride events. Analyses will test effects. Theoretically, findings will validate these frameworks in LGBTQ sport consumer contexts, showing how signal cost and observability shape perceptions. Practically, results may guide teams to use consistent advocacy and offer both explicit and subtle products, tailoring strategies to consumers�˘â‚Ĵ™ advocacy tendencies to foster engagement and loyalty.

Description

My lab investigates the sensory and neural control of juvenile social behaviors using poison dart frogs and their tadpoles. We use integrative approaches to understand how tadpoles make complex social decisions about their parents, how parent-offspring interactions shape brain and sensory development, and how early-life factors (both social and environmental) influence life-long changes in behavior. Research includes behavior observations and molecular and histology lab work. Additional projects related to how toxins impact social behavior, hormonal modulation of social behavior, and developmental neurobiology are also possible.

Description

Ischemic injury, which occurs when the retina doesn't get enough oxygen or nutrients, is a major cause of vision loss in diseases like diabetic retinopathy (DR), glaucoma, retinopathy of prematurity (ROP), and retinal vessel blockages. Research from our lab and others shows that too much activity in the arginase/polyamine pathway contributes to this damage. An important enzyme in this pathway, called ornithine decarboxylase (ODC), helps turn L-ornithine into a molecule called putrescine, which is then used to make polyamines. These polyamines are found at high levels in the eyes of patients with DR and in mouse models of retinal disease, and they appear to worsen retinal injury. However, the exact way polyamines cause damage is still not fully understood. My studies aim to fill this gap by exploring how increased polyamines lead to neurovascular damage in the retina, with the goal of finding new ways to protect vision.

Description

The Baltzegar Lab studies rapid evolution that occurs in response to human-induced changes to the environment in insect vectors with human-health importance, including mosquitoes in the Aedes genus and the German cockroach, Blattella germanica. While primarily using population genomic approaches, we address our questions from an interdisciplinary perspective with the goal of improving human health outcomes by advancing vector management techniques through better understanding of vector biology. Current projects include: Rapid evolution in an insect vector of disease, range expansion of a disease vector in a changing climate, urban evolution of insecticide resistance with complex socio-economic dimensions, and the evolutionary history and identification of the glucose-averse gene in the German cockroach, Blattella germanica.

Description

Chemosensation, primarily associated with olfactory systems, is emerging as a critical factor influencing various physiological processes beyond traditional sensory perception. Recent evidence suggests that olfactory receptors (ORs) a are expressed in diverse tissues, including immune cells like macrophages and monocytes, where they may play a role in disease regulation. This project aims to investigate the role of chemosensation in the progression of metabolic diseases and cancer. Specifically, we will explore how endogenous metabolites, pheromone-like molecules, and dietary compounds interact with chemosensory receptors to influence cellular signaling, inflammation, and disease progression.

Description

Get Fit! With Math & Lit is an after school program for youth that takes place at the HUB. The program occurs two times per week and promotes mathematics, reading, and writing through physical activity. Get Fit! utilizes the Teaching Personal and Social Responsibility model along with Culturally Relevant Pedagogies to create an environment that fosters a sense of belongingness while promoting holistic youth development. We focus on a word of the day that is a life skill, physical activities, and journaling.

Description

The purpose of this study is to determine if inhaling essential oils decreases pain-pressure threshold. Pain is felt when messengers in the body, called neurotransmitters, send signals to the brain. Essential oils can chemical constituents that might change how these messengers work, possibly making pain feel less intense. We will test four specific essential oils and one placebo to see if any help lower the level at which pain is perceived. The results of this study could help us understand if inhaling essential oils can be an effective way to reduce pain. Currently Full

Description

"Who are you?" is a question that we, as a social creature, intuitively ask whenever we interact with other people. For instance, we may think of some people as ÂéĥıAV students and others as University of Georgia students. The answer to this question often shapes how we will view and interact with another person. According to the Social Identity Theory (SIT; Tajfel & Turner, 1979), the classification of ourselves and others into groups creates a filtered version of how we perceive other people and the world. In other words, how we view other people, and the world may not always represent objective reality but rather a distorted version of it based on our expectations. It is this filtered reality, what psychologists call perception, that underlies multiple related research projects from the Social Perception Research Interest Group (SPRIG).

Description

The rapid convergence of technology and sports has given rise to innovative spectator experiences, with the TMRW Golf League (TGL) standing at the forefront of this revolution. As a technology-infused sports league, TGL integrates advanced digital elements to the traditional game of golf, creating a dynamic, immersive environment for spectators. Understanding how these novel elements influence spectator engagement, satisfaction, and behavioral responses is critical for both academic inquiry and industry stakeholders. This project aims to leverage artificial intelligence (AI) techniques to explore and analyze TGL spectators�˘â‚Ĵ™ responses, offering valuable insights into their cognitive, emotional, and behavioral interactions with the sport. By applying AI-driven methodologies such as natural language processing (NLP), sentiment analysis, and machine learning (ML), the study will provide a deeper understanding of spectators' perceptions, preferences, and future engagement intentions.

Description

This project is to develop novel treatment strategy for pediatric brain tumor using immunotherapy and chemotherapy. Both in vitro cell culture and animal models will be used to test the new therapeutics. Applicant has the chance to learn basic molecular biology, immunology and cell biology research techniques, apply training grant from pediatric tumor foundation.

Description

The neurons in our body extend long axons connecting to all parts of our body and form synapses with other neurons. Many synaptic proteins are generated in the cell body and have to navigate through long (up to meter) and highly branched axons. This is mediated through microtubule based motors kinesins and dyneins. Defects in transport of proteins contributes to a number of neurodevelopmental and neurodegenerative disorders. Research in the Tymanskyj lab investigates the mechanisms that regulate intracellular transport and neuronal morphogenesis. To do this we utilize a number of cell biology techniques such as molecular biology, cell and neuronal culture, optogenetics, live imaging and proteomics. These studies provide a foundation for understanding the cellular basis of an important fundamental question in neuronal development and provide insight into the mechanisms underlying neurodevelopmental and neurodegenerative disorders.

Description

Students will explore storytelling through text and images by creating and designing Graphic Novels and Zines to self-publish and distribute through Printed Matter in NYC and FLUKE (a national zine conference) in Athens, GA. Students have a foundation in illustration and image sequencing and this project will require learning, researching, and developing creative strategies needed for narrative and concept development specific to Zines and Graphic Novels. Printmaking has a long history in social and political activism, through self-publishing small editioned books and pamphlets or hand-printed illustrated broadsides. Students will be encouraged to choose a topic of research and aesthetics for their Zine. After completing their Zines and Graphic Novels, students will follow the submission process for Printed Matter in NYC and FLUKE, a national conference in Athens, GA.

Description

The Constructive Mathematics Pathways Leveraging Experiences for Advancing Prospective Teachers�˘â‚Ĵ™ Learning project aims to enhance the learning experiences of prospective elementary teachers (PSETs) in acquiring mathematics knowledge. This is achieved through inquiry-based exploration of the role of mathematics in other STEM disciplines and the development of sustainable teaching practices. An innovative ACE (Applying, Connecting, Experiencing) model will be implemented to foster an active learning environment for PSETs. The project employs mixed methods to evaluate its effectiveness in enhancing PSETs' mathematics and science teaching skills and changing their beliefs about these subjects. Undergraduate research assistants (UGAs) will support data collection by visiting university classrooms and after-school programs to gather survey data. UGAs will also assist in data analysis, including conducting statistical analyses and reviewing PSETs' reflection data.

Description

The purposes of this research are to (1) develop a model that can explain LGBTQ consumers' purchase intention on sporting goods, (2) examine the mediator role of product design preference and satisfaction in the relationship between internalized homonegativity and LGBTQ consumers�˘â‚Ĵ™ purchase intention, (3) examine the moderator role of self-esteem in the relationship between internalized homonegativity and LGBTQ consumers�˘â‚Ĵ™ product design preference. The authors will consist of two experimental studies: 2 (internalized homonegativity: high vs. low) x 2 (self-esteem: high vs. low) and 2 (self-esteem: high vs. low) x 2 (product design: blatant vs. subtle). The expected satisfaction and purchase intention are dependent variables in both studies. The authors will collect 200 samples using Prolific. The data will be analyzed using SPSS by conducting two-way ANCOVA. This research may contribute to both the LGBTQ community and the sports industry by suggesting effective marketing strategies.

Description

My lab focuses on two main areas of study: -Ectothermic (cold-blooded) animal ecology, systematics, and biogeography -Use of the global network of natural history collection specimens and data to ask complex questions I am looking for a student interested in ecology/systematics/biogeography OR computer science - specifically querying large datasets or using machine learning and applications in diverse, heterogeneous data A project in one of these areas might focus on exploring distributions or ecology of a particular group of fishes, reptiles or amphibians OR might be focused solely on the use of computing power and bioinformatic tools to explore large datasets.

Description

Non-native Invasive plants in the ÂéĥıAV Area are prevalent and reduce the biodiversity of our ecosystems. The student(s) will work to remove invasive plants from a riparian forest at Reed Creek Nature Center and then monitor the recovery of this ecosystem. Monitoring will include using plots to determine the growth of native plants after the removal of non-native plants. Planting and monitoring of native plants may also be needed.

Description

Student(s) will install and monitor wildlife trail cameras on Riverwatch Parkway to determine the risk of wildlife crossings. Riverwatch Parkway has a concrete barrier in the center that prevents safe passage of many wildlife species. The student(s) will determine what species cross the highway and the quantity of animals detected.

Description

Lumbriculus variegatus (blackworms) are used as model organisms to study water quality and environmental pollution. The aim of this project is to develop reliable bioassays with these organisms. Initial experiments will explore biotransformation reactions, including cytochrome P450 detoxification, which can serve as biomarkers of contaminant exposure. While these pathways are well-studied in vertebrates and some invertebrate groups, there is little information on these reactions in blackworms. Students will gain experience in several areas, including handling of the worms, dose calculation and preparation, and spectrophotometry. Initial tests will take place in a lab setting, but field sampling may follow once a successful procedure has been developed.

Description

Therapy-induced neuroendocrine prostate cancer (NEPC), an extremely aggressive variant of castration-resistant prostate cancer (CRPC), is increasing in incidence with the widespread use of highly potent androgen receptor (AR)-pathway inhibitors (APIs) such as Enzalutamide (ENZ) and Abiraterone. Neuroendocrine prostate cancer arises via a reversible trans-differentiation process, referred to as neuroendocrine differentiation (NED), wherein prostate cancer cells express neuronal characteristics. The molecular basis of NED is not completely understood leading to a lack of effective molecular markers for its diagnosis and effective therapy. Our research is focused on understanding mechanistic basis of this trans-differentiation, identifying novel molecular biomarkers for effective diagnosis of this variant and defining novel therapeutic strategies. We are using engineered exosomes to define novel therapeutic strategies for prostate cancer.

Description

The immune system is endowed with the capacity to distinguish between self and non-self, a phenomenon referred to as immune tolerance or "immune consciousness." However, a breakdown in such tolerance mechanism can lead to a spectrum of autoimmune diseases, where the immune system initiates attacks on various organs within the body. In our laboratory, we are deeply interested in understanding the extent of the immune system's consciousness and how a loss of this awareness can contribute to disease development through intercellular communication, particularly among different T cell types. We have recently published a paper demonstrating that a specific subtype of T cells, activated memory T cells, can engage in cross-talk and modulate the behavior of another subtype, naive T cells (Sasaki et al., 2022, Nature-CommsBio).

Description

In this project, we develop artificial intelligence (AI) algorithms that can create novel treatments for untreated diseases, considering the growing need for AI technology in drug development and the steady expansion of drug databases. The goal is to find a molecule that can chemically bind to the target protein and modulate it so that it no longer contributes to the disease.

Description

Epilepsy is a neurological disorder identified by the frequent occurrence of seizures in which the patient might lose awareness. The seriousness of this condition is centered on the sudden occurrence of seizure events. Predicting seizures would be a pioneering healthcare solution that would improve the quality of life of epileptic patients. Current machine learning methods have high computational costs and hence high energy consumption which restrict their use in the real-time operation of wearable devices. Spiking neural network (SNN) is an emerging brain-inspired architecture where artificial neurons compute only when separate events are received, leading to an energy-efficient computing method. Current SNN algorithms suffer from some limitations related to input data mapping and the inability to predict new cases with high accuracy. This project aims to develop a novel SNN approach that overcomes these problems to help predict seizures with high accuracy and low power in real-time.

Description

Zebrafish is an ideal tool for direct In-vivo observations of developmental processes. To conduct in-vivo whole organism imaging studies, skin transparency is a primary requirement, necessitating the blocking of pigmentation. Zebrafish casper mutant maintains skin transparency throughout its life, offering the ideal combination of sensitivity and resolution for in-vivo analyses and imaging. Our Laboratory developing a novel transparent transgenic zebrafish model to address basic cardio-oncology and experimental therapeutics. The fli1 promoter in zebrafish has an enhanced expression reporter gene of green fluorescent protein, GFP. This model will allow for in-vivo examination of the vascular system by using fluorescent and confocal microscopy. In this study, we develop a transparent transgenic strain of Caspe/fli1:EGFP and Casper/myl7/annexin-5:YFP and Casper/fli1:EGFP strain through crossbreeding of proposed lines. This proposed study will aid new dimensions in Cardiooncology research

Description

Patients with systemic lupus erythematosus (SLE, commonly called lupus), a devastating autoimmune disease that preferentially targets African Americans and women of childbearing age, are at high risk for cardiovascular disease due to accelerated atherosclerosis. The proposed project will define mechanisms of perivascular adipose tissue (PVAT) in the development of lupus-associated vascular disease. In this project, we will use lupus-prone mice to study the immunological and molecular changes of PVAT. In addition, we will isolate preadipocytes and use 3T3-L1 cell line to study the metabolic characteristics in the context of lupus. Furthermore, we will use a model of combined PVAT transplantation and wire injury to investigate the vascular remodeling in lupus.

Description

The consideration of random hypothesis in studying some influencing factors affecting the growth or decline of a tumor is crucial. By analyzing the effects of stress on the volume of tumor growth in a random environment, we develop stochastic models describing the dynamics of the tumor growth based on random adjustments to the population�˘â‚Ĵ™s intrinsic growth rate, carrying capacity, and tumor treatments. Apart from the models�˘â‚Ĵ™ ability to capture fluctuations, the availability of a shape parameter in the models gives it the flexibility to describe a variety of population/tumor data with different shapes. The distribution of the stressed population size is derived and used to calculate the minimum amount of chemotherapy needed to cause shrinkage or eradication of a tumor. This work is applied to analyze tumor growth of breast tumors obtained by orthotopically implanting LM2-4LUC+ cells into the right inguinal mammary fat pads of 6 to 8-week-old female Severe Combined Immuno-Deficient mice.

Description

After successfully completing an Applied Research course in the French program that focused on reading and analyzing a particularly challenging French text, then critical articles and a book, as well as doing applied research assignments, all designed to teach applicable skills suitable for a future lawyer, the student and professor have been invited to submit an article for consideration at a peer-reviewed journal. This project would be to research and then write and submit that article. The student will work with the faculty member as they produce a joint article

Description

Recent studies have provided substantial genetic evidence linking soluble epoxide hydrolase (sEH) to AD/ADRD. Our prior research has substantiated that inhibiting sEH effectively alleviates cognitive deficits in rat models of AD/ADRD by improving cerebral hemodynamics. To delve deeper into the underlying mechanisms, we employ a multifaceted approach, harnessing cutting-edge techniques. Furthermore, our lab has identified additional potential treatment targets for AD/ADRD grounded in genetic factors and preliminary investigations of vascular and behavioral aspects, which are currently undergoing detailed mechanism studies.

Description

We have Cybersecurity projects on different Internet of Things (IoT) environments and Cyber-physical systems. These projects include but are not limited to, security and privacy issues in smart grids, smart Healthcare systems, and Vehicular networks. The aim of these projects is to address the privacy and security challenges by employing machine learning/AI models while using lightweight applied cryptography to preserve privacy. Cyber Security, Privacy, applied cryptography, IoT, CPS

Description

ORAN is a new technology being tested for 5G networks in the US. It is open, programmable, and virtualized, making it more flexible and cost-effective for operators. However, its open design and integration of AI also pose a significant security and privacy risk as cybercriminals could exploit vulnerabilities to launch attacks and access confidential information. To mitigate such risks, this Project aims to (1) develop a machine learning (ML)-based ORAN monitoring and threat analysis framework that continuously monitors, analyzes, and mitigates security cyber threats, (2) elucidate the impact of adversarial attacks on the ML-based ORAN applications and propose defense strategies against these attacks, and (3) develop cryptographic-based deception techniques to preserve the privacy of sensitive user/RAN data. The network performance, data privacy and security, and overhead of the proposed tasks will be evaluated using real 5G ORAN datasets.

Description

Premature birth is a major public health issue with a growing population of surviving infants. Clinical and laboratory studies demonstrate that environmental factors can benefit recovery from these disabilities, however specific mechanisms that drive the injury progression and repair are not well understood. Research in the Goldstein lab investigates the pathogenesis and repair mechanisms following developmental brain injury. To do this, we will examine brain tissue from mice housed in a low oxygen environment - a model of premature birth. We also will analyze postmortem human brain samples from babies that were born preterm. These studies will inform the quest to develop improved therapeutic options for babies born prematurely.

Description

The unprecedented growth of biopharmaceuticals in recent years has led to better ways of managing chronic diseases in humans including diabetes, immunodeficiencies, and cancer. As the number of approved drug compounds increases, there is a pressing need for lower cost, faster biomanufacturing operations to make these products available and more affordable for growing patient populations. This research project aims to develop numerical approaches to solve the mathematical descriptions needed to simulate these processes. Mathematical models must incorporate new, more complex ion-exchange relationships that define the solid phase adsorption as an implicit function of the liquid phase adsorption, a significant change from the standard explicit mathematical relationships. The goals of this project are to develop, validate, analyze, and use computational tools to inform the design of new, rapid membrane chromatography purification processes for biomanufacturing environments.

Description

Vaccine hesitancy can pose a significant threat to people and leads to loss of herd immunity and the recurrence of COVID-19. The overall goal of this study was to assess the mortality and vaccine hesitancy among hospitalized COVID-19 patients. A retrospective data analysis of COVID-19 patients�˘â‚Ĵ™ data. A fixed convenience sample of 927 admitted patients aged 18 or above admitted from March 1 to November 30, 2021. Descriptive statistics, bivariate logistic regression, and survival analysis were used.

Description

The overall aim of this study is to utilize Church Health Workers (CHWs) to screen for depression among COVID-19 survivors in a Black church and compare the effectiveness of Screening, Brief Intervention, and Referral to Treatment (SBIRT; Intervention arm) to individuals as Referral As Usual (RAU; Control arm/Usual Care arm) on treatment engagement for depression. Aim 1: To compare the effect of SBIRT (Intervention arm) among COVID-19 survivors to subjects as Referral As Usual (RAU; Usual Care arm) on treatment engagement Aim 2: To assess changes in mental health outcomes at 3- and 6-months post-screening among COVID-19 survivors. Aim 3: To identify contextual factors that act as facilitators or barriers of depression screening and referral among COVID-19 survivors. We hypothesize that Church Health Workers (CHWs) deployed for church-based depression screening can help overcome cognitive barriers and increase treatment engagement among black COVID-19 survivors.

Description

Bicaudal-D (BicD) is a cargo adaptor for the Dynein motor. Mutations in BicD in humans is associated with a type of spinal muscular atrophy, a generative neurological disorder. The goal of this project is to use mammalian cells lines and the Drosophila melanogaster model to determine the molecular defects that contribute to the disease pathology.

Description

The overall goal of my laboratory is to better understand the molecular mechanisms that regulate blood pressure (BP) and renal health and function in males and females under both physiological and pathophysiological conditions. Ongoing projects are examining the role of immune cells in the development of essential hypertension, and increases in blood pressure on a high fat diet. We are also examining the mechanisms that induce renal injury following ischemia., and the long term impact of this on pregnancy.

Description

Students in ART 4261 will explore storytelling through text and images by creating and designing Graphic Novels and Zines to self-publish and distribute through Printed Matter in NYC. This project will require learning, researching, and developing creative strategies needed for narrative and concept development specific to Zines and Graphic Novels. Students will be encouraged to choose a topic based on personal, contemporary social, or political issues. Students must ask questions that engage their audience by identifying issues that intersect in areas of common identity and work towards building consensus rather than division. After completing the small edition Zines and Graphic Novels, students will follow the submission process for Printed Matter in NYC. Printed Matter is one of the largest distributors of self-published material in the world. If the student's work is accepted, they are required to have or make a minimum edition of 100 for distribution.

Description

The focus of this project is to assess the impact of cardiovascular risk factors such as blood pressure variability, hypertension and heart failure on the early onset of cognitive decline and dementia. We use an array of methods including behavioral studies, confocal imaging, live in vivo imaging (two photon microscopy) and molecular and cellular approaches. We investigate how different cells of the neurovascular unit (astrocyte, neurons and vascular cells) communicate, and how these processes are affected in diseased conditions contributing to a decline in neuronal function.

Description

Please note Dr. Hoffman is NOT taking on students for Spring 2024 The Hoffman lab is interested in the biology of aging and understanding the genetic, metabolic, and environmental factors that influence aging across species. There are multiple projects available undergraduate researchers using the fruit fly as a model for discovering interventions to increase lifespan and improve health. Current ongoing studies in the lab include manipulating the amino acids tryptophan and serine, as well as performing dietary restriction studies. There are also opportunities to study evolution and life history trade-offs (longevity and reproduction) in the fly. Undergraduate researchers have the potential to develop their own intervention experiment or work on any of the projects already started in the lab. Please reach out for more information, as well as a more detailed description of the potential projects.

Description

This is a feasibility study - meaning we will use new techniques (also in a new lab space) to ensure everything works as anticipated. If we run into issues, we will troubleshoot and determine the correct course of action. :) Once we have perfected our methods, we will recruit healthy participants and run our feasibility study. Pain-Pressure Threshold (PPT) is when a non-painful stimulus induces nociception (pain) and is measured by a hand-held algometer. Many essential oils (EOs) have pain-reducing properties, but have not been well-studied. Topically-applied EOs may increase PPT, thus, reducing pain perception. PPT will be measured with control, jojoba, and 16 single diluted EOs in healthy adults using a quasi-experimental, within-subjects design. Additionally, we will use digital infrared thermal imaging (DITI) to ascertain EO absorption spread. Study results will support using PPT in future studies using EOs for chronic pain. Funded: Beta Omicron Chapter, STTI & my start-up funding.

Description

The development of new drug candidates for cancer treatment is a complex and challenging process. However, recent advances in molecular hybridization (MH) and rational drug design (RDD) approaches have provided new opportunities for the creation of more effective and targeted cancer therapies. By combining different molecular structures and optimizing their properties, scientists can create hybrid molecules with enhanced properties and reduced side effects. This approach allows for the creation of drugs that specifically target cancer cells while leaving healthy cells unharmed. Additionally, the RDD approach involves using computer simulations and molecular modeling to predict the effectiveness of potential drug candidates. Overall, the use of MH and RDD approach offers great promise for the development of new cancer therapies. With continued research and development, these approaches may lead to breakthroughs in the fight against cancer.

Description

Trauma-induced injury of the retina and optic nerve is a major cause of vision loss with few effective therapies. We seek to delineate the molecular mechanisms of the injury and identify novel strategies to prevent or reverse the damage and preserve vision. We are studying the role of an enzyme called arginase 1 in this process. We have discovered that arginase 1 deletion worsens the damage, whereas treatment with a stable drug form of arginase 1 limits injury and promotes repair by decreasing inflammation and increasing immune cell repair functions. Pharmaceutical forms of this drug are currently under development as cancer therapy. Thus, the treatment is safe for use in patients and can be readily adapted for treating trauma to the retina or optic nerve. Our current studies are expanding this work to further demonstrate its protective effects in models of traumatic optic nerve injury and glaucoma and elucidate the underlying mechanisms.

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Our lab's primary focus is understanding cancer resistance to DNA damage-inducing therapeutics like irradiation with the ultimate goal of identifying a noble therapeutic target and developing more effective treatment strategies to improve patient survival.

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We have various projects to work on. It ranges from Blockchain technology to cryptography. All the projects are in the area of computer security and privacy. Our research aims to implement the ideas that have been shaped using your current skills while learning more about security and privacy.

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A census of frog populations of aquatic habitats in South Carolina; Aquatic turtle species composition, population evaluation, and environmental toxicology

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The main goal of the project is to identify the mechanisms leading to hypertension in obesity and to determine whether these mechanisms are sex-specific. Experiments will include characterization of the cardiovascular phenotype of mouse models of obesity and collaboration with clinicians working with human patients.

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Uses a multilevel approach to investigate forebrain networks involved in encoding and consolidating of memories for emotional events in models of anxiety and impaired cognitive flexibility with special focus on individual differences. The lab has created an animal model of susceptibility for developing Post-Traumatic Stress Disorder. She serves on grant study review sections for NIH, NSF and DOD, and also reviews grants for the VA and the ÂéĥıAV Biomedical Research Corporation. She is a reviewing editor for Frontiers in Molecular Neuroscience.

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Focuses on the identification and characterization of molecular targets of brain injury after intracerebral hemorrhage, a fatal stroke subtype employing both genetic and pharmacological approaches. Serves on AHA study section.

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Studies the interactions of aging and circadian rhythms in vascular disease. The molecular focus is in identifying the contributions of the transcriptional mechanisms that operate in the inner cell layer of the blood vessel called the endothelium. In addition, there are new areas of research that are unfolding in the lab, which seek to query if and what molecularconnections exist between the aging blood vessel and the aging brain, with potential application to Alzheimer's Disease.

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Our research is centered on identifying genes and genetic processes essential for the generation of neurons during mammalian embryonic development, understanding the the underlying molecular mechanisms, and using these genes and processes for neuroregeneration by promoting the differentiation of neural progenitors into neurons.

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In my lab we look at how cells communicate during the development of the fruit fly (Drosophila melanogaster) as it grows from a single cell to a multicellular animal. We take a synthetic approach, which means we investigate how cells communicate by designing news forms of communication and testing them to see if they work. The investigation is relevant to the fundamental understanding of how animals, including humans, develop and also has potential applications in regenerative medicine, tissue engineering and anti-cancer therapies. Students build skills related to fly genetics, molecular biology, the presentation of their work to a wider audience and scientific problem solving.

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Background and Purpose: Vascular dysfunction and resultant chronic cerebral hypoperfusion leads to vascular cognitive impairment (VCI), the second most common cause of dementia. We reported that Remote Ischemic conditioning (RIC)-therapy improves cerebral blood flow (CBF) in both murine stroke and VCI models. RIC is a non-invasive, simple, inexpensive, and safe use of repetitive inflation of a blood pressure (BP) cuff on the arm or leg to protect distant organs such as the brain from ischemic injury. We have some preliminary data after Bilateral Carotid Artery Stenosis (BCAS) in the mouse (model of VCI) that daily remote ischemic postconditioning (RIPostC) using a BP cuff for 2 weeks increases CBF in a sustained manner, improves cognitive performance, and decreases aggregation of amyloid-beta 42 protein (A?42) in the brain. Our central hypothesis is that RIPostC therapy after BCAS improves cognitive function in animal model of vascular cognitive impairment (VCI).

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The research projects available in my laboratory run the gamut from cognitive neuroscience to artificial intelligence. We use a variety of approaches, including those of cognitive psychology, brain imaging, and computational methods, primarily in clinical and translational settings (please see my website, www.hegde.us). I do my best to match the project to the aptitudes, interests and the plans of the student.

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In this research project we are analyzing economic texts from the 19th and 20th centuries. The goal is to understand how the concept of productivity has evolved over time, specifically whose work and what activities get included and excluded from being defined as economically productive. This is central to understand given that productivity is a key metric we use to define the value and worth of people and their activities. The method we will use to understand this is the historical analysis of economic textbooks and canonical economic texts. We have a body of textbooks from 1890-1960 at the moment, but need to extend that sample backwards earlier into the 1800s and expand it outwards to include not just textbooks but canonical economic texts.

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Cancer of the colorectum (CRC) is one of the most common cancers in the world, representing about 8% of allannually reported cancers. Chemoprevention of CRC development is, therefore, a priority for people at high risk,though no drugs are currently available for this unmet clinical need.This work is aimed at developing PDE5 inhibitors (PDE5i) for colon cancer prevention. Novel PDE5i will showfewer side effects than existing PDE5i by designing their polar structural analogs to affect the gut lining whileminimizing entrance into the bloodstream. Our strategy is to design novel localized PDE5i's that remain in theGI tract to specifically target GI diseases. As proof of principle, we have synthesized and tested 2 novel polaranalogs of sildenafil: malonyl sildenafil and boronyl-sildenafil. Our central hypothesis is to develop and test newgut localized analogs of sildenafil that have been proven to be effective in colon cancer prevention in preclinicalmodels. Our long-term goal is to develop a family of gut-localized, safe, and effective drugs that can be usedfor colon cancer prevention. The objective of this proposal is to develop a library of structurally optimized novelchemical entities and determine their efficacy at inhibiting PDE5i in vitro and in mice. The research approachesused in this project will be implemented in the existing Medicinal Chemistry undergraduate program at ÂéĥıAVUniversity. This project blends the expertise of medicinal chemistry and biology and their roles in early drugdiscovery. Both the drug design and biological testing reflect the key steps in the pharmaceutical industryworkflow for drug development.

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Role of VEGF-A isoforms in regulating angiogenesis in Peripheral Artery Disease (PAD)

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Dr. Dinesh Hasija invites undergraduate students interested in business, politics, and global strategy to join his research team. His work explores how companies make strategic decisions in complex environments�˘â‚Ĵ”focusing on corporate governance (boards and CEOs), mergers & acquisitions, and the role of corporate political activity (like lobbying) in shaping business outcomes. Students will gain experience in data collection, literature review, and analysis while contributing to projects that connect business strategy with real-world political and economic challenges.

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Our laboratory is focused on understanding the regulation of cellular energetics in aging and injury. Multiple different projects are available for motivated undergraduate students interested in gaining hands-on experience in biomedical research. Current research programs are supported by grants from the Department of Defense and the National Institutes of Health. If you are driven, motivated and want to learn more, join our program. Opportunity for co-authorship in publications.

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Over 40 million Americans experience chronic pain. Chronic pain creates an enormous burden on the U.S. economy through lost work and direct healthcare and medication costs totaling 600 billion dollars annually. This burden is compounded when coupled with pain-related co-morbid conditions such as anxiety, depression, and ineffective sleep. Of Americans with chronic pain, over 6.5 million experience pain that is neuropathic in nature. Neuropathic pain has been described as prickling, tingling, burning, and electric shock-like sensations and is difficult to treat. Pharmacological approaches to neuropathic pain are minimally effective and accompanied by adverse effects such as dry mouth, weight gain, and cognitive and sexual dysfunction. Aromatherapy is a novel approach to chronic neuropathic pain. Aromatherapy is the use of essential oils (EOs), extracted from aromatic plants, to support health by eliciting physiological and psychological effects primarily through inhalation and topical-application. EOs moderate many aspects of pain signal transmission including non-competing inhibition of 5-HT, AChE, and Substance P, and antagonism of TRPA1 and TRPV1. Local thermal hyperemia (LTH) is an innovative method of testing local sensory neurons' release of substance P in response to a heat stimulus. In an earlier within-subjects study, a blend of six EOs demonstrated 13% substance P inhibition compared to placebo. The purpose of this study is to determine the effect of select EOs on substance P and nitric oxide during LTH to enhance an intervention for neuropathic pain. Study results will be used to support a NCCIH natural products for pain reduction R-21 grant application.

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Effects of endocrine disruptors on cellular and reproductive physiology. All projects are student led, with current projects examining the effects of PFAS chemicals on both breast cancer cells and steroidogenic cells in the ovaries and testes.

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*Not taking students Fall 2025*

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We are currently exploring a new model for hypertension and performing in vivo studies. These techniques have not been published yet. Relevant topics can be found in pubmed such as https://pubmed.ncbi.nlm.nih.gov/33101063/,https://pubmed.ncbi.nlm.nih.gov/33410092/

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Neural and sensory cell regeneration

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The goal is to better understand how neurons transduce external stimuli downstream to discrete spatiotemporal patterns of second messenger signals. Integration of signaling events enables neuronal networks to communicate with high fidelity where anomalies in signal decoding mechanisms can have pathological consequences. To uncover the molecular logic utilized by neurons to interrogate a diversity of signaling events, we will investigate the contributions of key elements in the molecular pathways downstream of neurotransmitter stimulation. This will be achieved through CRISPR/Cas9 gene editing in neurons expressing biosensors that report cellular activity observable through fluorescence microscopy. The project will additionally use lenti- and adeno-associated virus technology to manipulate gene expression as well as molecular cloning approaches.

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Signaling for the treatment and prevention of intestinal disease. My laboratory aims to understand tissue renewal in the colon, and how this can be manipulated to treat ulcerative colitis and for the prevention of colon cancer. We discovered that increasing cGMP levels with phosphodiesterase inhibitors (e.g. Viagra) can protect the colon epithelium and slow it's turnover. This is therapeutic in mouse models of colitis and colon cancer. We work with colon cancer cell lines, human and mouse intestinal organoids, andmice disease models.

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Development of Transgenic Zebrafish Model Organism to study the cardiomyocyte and Microglia Function in health and disease condition with special reference to the Inflammatory process (NFkB) and Apoptosis (Annexin-V) in Brain Tumor and Heart disease. EGFR/sEGFR-Breast Cancer Research, Role of soluble isoforms (extracellular domains) of EGFR Family members in targeted therapeutics and establishment of sEGFR as Biomarker in Cancer Research. In-vivo automated HTS Drug Discovery by using Zebrafish model in Diabetes beta-cell neogenesis and proliferation, Creation of acute hypoxia in the zebrafish model and its impact on Cardiovascular Biology.

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My research is focused on miRNA-mediated mechanisms during CNS development and after spinal cord injury (SCI). In addition, I combine the in vivo reprogramming technology with miRNA biology to induce miRNA-mediated neuronal reprogramming from endogenous reactive glial cells for SCI functional repair. Approaches include animal work, cell culture, molecular cloning, etc.

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Study involves microfluidics: selected sstudents will be looking at drop sizes, generation frequency, etc.

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We present a mathematical model describing the transmission of certain diseases with multiple strains and explore the effects of vaccination and treatments on such diseases. The effects of external fluctuations caused by factors like the rates at which testing of such disease is done, vaccination rates, variability in the number of contacts between infected and susceptible individuals, mask use per capita, social behavior, public health intervention, and so on, is also investigated. The probability distribution of the number of infections at a given point in time is also obtained.

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Area of research: Mathematical Biology

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Nanoparticle Delivery and Tracing Project: This project focuses on engineering nanoparticles for targeted delivery and precise tracing within biological systems, establishing platforms to monitor distribution, uptake, and therapeutic potential in vivo. Cell Death Control in Ischemic and Chemotherapy-Induced Kidney Injury Project: This project investigates the molecular pathways that regulate cell death in ischemic and chemotherapy-induced kidney injury.

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Investigates role of cholinergic systems in memory function, and how it is altered by diseases like schizophrenia and Alzheimer's Disease as well as toxins that are found in the environment such as organophosphate insecticides. He serves on NIH and DOD Study sections and is the current Secretary of the Association of Medical School Pharmacology Chairs (AMSPC).

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In today's world it is becoming more and more important to understand the foundation of human life. Human molecular evolution is now the subject of copious amounts of research about how our species has evolved. Differences in gene and protein expression can be subtle yet extremely impactful. Advancements in genomics clearly reveal how differences in gene expression impact human health and physiology. As technology continues to improve, it becomes possible to gain a more accurate picture of what each gene contributes to the human body. Principles of Human Anatomy & Physiology –I & II are required courses for students who like to pursue their career in the health related field (e.g. – Pre-Med, Physician Assistant, Nursing, Physical Therapy, Nuclear Imaging, etc). Traditionally it has been observed that majority of the students taking these courses struggle due to the complexity of the human body. Primary purpose of my pedagogical research is to develop and provide students with active learning modules and/or resources for their better understanding of the concepts associated with anatomy and physiology.

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CrossFit has become a phenomenon of exercise modality in the past decade. It has also been a controversial mode of exercise since it gained popularity in the early 2000s and has seen itself in the light of critics on more than one occasion. The CrossFit philosophy is comprised of what researchers consider embracing individuality, “buying into” the CrossFit culture, and a singular commonality. This project will focus on the last of the three: the singular commonality. Researchers have deemed this term to reflect a willingness to adopt the CrossFit lifestyle in order to improve themselves (Belger, 2012; Dawson, 2017; Herz, 2014; Murphy 2012). One could argue that within this community, by being surrounded by like-minded individuals, a sense of inclusion, belonging, and connectedness to CrossFit is established. However, over recent years, CrossFit has found itself in the spotlight for instances that call into question the inclusive nature it preaches. This project is meant to explore the sense of belonging BIPOC and marginalized identities have within their CrossFit space. This project is a mixed method study examining a sense of belonging through quantitative measures (Sense of Belonging Instrument, Hagerty & Patusky, 1995) and exploring the emotions behind the numbers, giving life to the narratives of those who remain committed to CrossFit through interviews. This project will become a significant hub of data that will allow for further exploration of the acceptance of these gym members within the CrossFit community and how the CrossFit community can expand its support for marginalized communities.

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Natural products (NPs), secondary metabolites biosynthesized by microorganisms and plants, are a very important source of drugs and drug leads. Infectious diseases, atuoimmune diseases, and other ailments have been treated by these molecules throughout human history. In ancient times, crude drugs that are dried and/or ground organism matters were used to treat these diseases. The clinical use of NPs was greatly intensified by the discovery and isolation of the first pure antibiotic penicillin in 1928. NP drugs generally have high selectivity (less adverse effects) thanks to their complex chemical structures. In the past 40 years, more than 60% of U.S. Food and Drug Administration (FDA) approved small molecule drugs have been NP related. However, a new threat has been appearing in recent years. According to the World Health Organization, infections by antibiotic-resistant pathogens are increasing globally and are anticipated as one of the greatest threats to human health in the future. Therefore, new drug candidates for use in clinics are in high demand. This project aims to characterize a biochemical process called homologation of amino acids. Homologation is a reaction that adds one carbon on the amino acid side chain, which results in production of an uncommon amino acid that has one-carbon longer side chain. Homologated amino acids are produced by the enzymatic pathway that involves five enzymes, and the resulting compounds are used to produce biologically active NPs with higher selectivity and/or stability. By understanding the pathway and engineering it to apply to production of other NPs, it will be possible to produce new NPs with enhanced bioactivity, bioavailability, and biostability.

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