Faculty Profile | Alison Kriegel, PhD, FAHA
Alison Kriegel, PhD, FAHA
About Alison Kriegel, PhD, FAHA
My research program aims to understand molecular mechanisms regulating cardiovascular and renal physiology and disease. I enjoy working as part of multidisciplinary teams and mentoring students and early career researchers.
Research Focus
My research interests are broadly focused on understanding how alterations in microRNAs (miRNAs), protein coding genes, and metabolites influence cardiovascular disease, cardiorenal syndrome, and renal disease. We utilize discovery-based approaches to studying these complex problems by blending next-generation technologies with molecular biology techniques, systems physiology, classical physiological studies, and translational research.
Our current work is focused in three main areas:
1) determining mechanisms regulating declining renal function in hypertension, diabetes and CKD,
2) determining mechanisms regulating cardiovascular dysfunction in cardiorenal syndrome and during cancer treatment, and
3) understanding fundamental sex differences in renal and cardiovascular physiology and pathophysiology.
Academic Focus
Courses spanning disciplines of anatomy, physiology, cell biology, molecular biology, genetics/genomics and graduate-level research skills.​Research ​mentorship ​for trainees ranging from undergraduate students to early career faculty.
Education & Credentials
Ph.D., Physiology, General Medical College of Wisconsin, 2008
BS., Biological and Biomedical Sciences, Medical College of Wisconsin, 2001
Laboratory Info
Lab Location
CA-3097
Publications
Publications
- Nasci VL, Liu P, Marks AM, Williams AC, Kriegel AJ . Transcriptomic analysis identifies novel candidates in cardiorenal pathology mediated by chronic peritoneal dialysis. Sci Rep. 2023 Jun 21;13(1):10051. doi: 10.1038/s41598-023-36647-7. PMID: 37344499; PMCID: PMC10284882.
- Williams AC, Singh V, Liu P, Kriegel AJ . Liquid Biopsies Poorly miRror Renal Ischemia-Reperfusion Injury. Noncoding RNA. 2023 Apr 1;9(2):24. doi: 10.3390/ncrna9020024. PMID: 37104006; PMCID: PMC10141369.
- Adam RJ, Paterson MR, Wardecke L, Hoffmann BR, Kriegel AJ . Functionally Essential Tubular Proteins Are Lost to Urine-Excreted, Large Extracellular Vesicles during Chronic Renal Insufficiency. Kidney360. 2020 Oct;1(10):1105-1115. doi: 10.34067/kid.0001212020. Epub 2020 Oct 29. PMID: 34263177; PMCID: PMC8276873.
- Nasci VL, Chuppa S, Griswold L, Goodreau KA, Dash RK, Kriegel AJ . miR-21-5p regulates mitochondrial respiration and lipid content in H9C2 cells. Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H710-H721. doi: 10.1152/ajpheart.00538.2017. Epub 2019 Jan 18. PMID: 30657727; PMCID: PMC6459316.
- Kriegel AJ , Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M. Isomer-specific effect of microRNA miR-29b on nuclear morphology. J Biol Chem. 2018 Sep 7;293(36):14080-14088. doi: 10.1074/jbc.RA117.001705. Epub 2018 Jul 13. PMID: 30006350; PMCID: PMC6130969.
- Chuppa S, Liang M, Liu P, Liu Y, Casati MC, Cowley AW, Patullo L, Kriegel AJ . MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4. Kidney Int. 2018 Feb;93(2):375-389. doi: 10.1016/j.kint.2017.05.014. Epub 2017 Jul 29. PMID: 28760335; PMCID: PMC5787401.
- Kriegel AJ , Gartz M, Afzal MZ, de Lange WJ, Ralphe JC, Strande JL. Molecular Approaches in HFpEF: MicroRNAs and iPSC-Derived Cardiomyocytes. J Cardiovasc Transl Res. 2017 Jun;10(3):295-304. doi: 10.1007/s12265-016-9723-z. Epub 2016 Dec 28. PMID: 28032312; PMCID: PMC5937699.
- Kriegel AJ , Baker MA, Liu Y, Liu P, Cowley AW Jr, Liang M. Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes. Hypertension. 2015 Oct;66(4):793-9. doi: 10.1161/HYPERTENSIONAHA.115.05645. Epub 2015 Aug 17. PMID: 26283043; PMCID: PMC4567475.
Lab Members
Lauren Yunker, Graduate Student