The Rajpurohit Lab
Surendra Rajpurohit, PhD, FAHA
Research Scientist
Department of Biochemistry & Molecular Biology
Medical College of Georgia
Department of Biological Sciences
College of Science and Mathematics
Georgia Cancer Center
Jump to: Research SummaryImpact on Georgia patientsResearch Focus Research Interests Publications
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The Rajpurohit Lab
Health Sciences Campus
1410 Laney Walker Blvd, CN 3117
(706) 721-0277
Research Summary
Dr. Rajpurohit’s lab is working on Experimental Therapeutics in Glioblastoma Tumor Microenvironment, and Cardio-oncology using an in-multi modeling system, which includes: In-silico modeling system, in-vitro modeling system, in-vivo transparent transgenic zebrafish and mouse models, and high throughput (HT) drug discovery, repurposing of FDA-approved drugs, identification of novel hit and lead drugs, and drug validation and drug toxicity in glioblastoma and cardio-oncology therapeutics.
The laboratory studies the cancer drug induced cardio toxicity, Identification of the novel drug candidate to mimic cancer drug induced cardio vascular complications, mitochondria function, cell death process (role of annexin 5 and inflammatory activity of NF-kB) in the microglia-resident macrophages of the brain (normal and in glioblastomas) and cardiac myocytes (normal and inflamed) in transgenic zebrafish and mouse models.
Impact on Patients in Georgia
Dr. Rajpurohit is addressing two converging threats to Georgia patients: glioblastoma, the deadliest brain tumor, and the cardiovascular damage that can result from the very cancer treatments that save lives.
Using innovative transparent transgenic zebrafish and mouse models that allow real-time visualization of cellular events, his lab is identifying new drug candidates and validating their safety in ways that bridge the gap between discovery and the clinic.
Equally important, Dr. Rajpurohit actively trains the next generation of biomedical researchers at Â鶹AV—investing in the scientific workforce that will continue to serve Georgians for decades to come.
Research Focus
Dr. Rajpurohit ’s research is focused on:
- Working on the Experimental Therapeutic in Glioblastoma and Cardio-oncology by using in-vivo transparent transgenic zebrafish and mouse models.
- Developing and establishing in-vivo transparent transgenic cellular phenotype model of zebrafish to study the cell death process.
- Repurposing of FDA-approved drugs.
- Identification of novel hit and lead drugs.
- Drug validation and drug toxicity in glioblastoma and cardio oncology therapeutics.
Research Interests
Validation & Toxicology Study of K21 Drug in Zebrafish Model
This project aims to evaluate the safety, developmental effects, and overall efficacy of a proposed drug using a zebrafish model. The study will follow a phased experimental design to assess impacts on developmental dynamics, growth, behavior, teratogenicity, and toxicity. Key goals include quantifying the drug’s effects across these parameters and determining its overall influence on zebrafish health. The findings are intended to establish measurable benchmarks for safety, biological impact, and support further development.
Experimental Therapeutics
The goal of this project is to design and implement experiments that involve the development and assessment of experimental therapeutics, using various animal model systems.
View Pure Research Profile
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, Manhiani, D. A. S., , Rajpurohit, P., Hotwani, S., Nasanally, S., Sreekumar, A., Bhat, K., Derhei, A. V., Pasi, R., Mishra, A., Kimmerling, K. & Carey, C. M., Jun 2025, In: Biomedicines. 13, 6, 1267. Research output: Contribution to journal › Article › peer-review |
, Ouellette, L., Sura, S., Appiah, C., O’Keefe, A., McCarthy, K., Kandepu, U., Ye Mon, M., Kimmerling, K., & , Jul 2023, In: Biomedicines. 11, 7, 1985. Research output: Contribution to journal › Article › peer-review |
Doughty, D., , Trang, A., Alptekin, A., Korkaya, A. K., Achyut, B. R., & , Aug 2022, In: Experimental Biology and Medicine. 247, 16, p. 1433-1446 14 p. Research output: Contribution to journal › Article › peer-review |
, Gopal, A., Ye Mon, M., & , Aug 2021, In: Cells. 10, 8, 1963. Research output: Contribution to journal › Article › peer-review |
Ullah, A., Doroodchi, A., Zarate, L. V., Mattox, S. N., Sliker, T., Willhite, D. K., Khan, J., Owen, H. C., , & , Apr 2 2021, In: International journal of environmental research and public health. 18, 8, 4157. Research output: Contribution to journal › Article › peer-review |
, Dec 1 2016, In: Nature Protocols. 11, 12, p. 2432-2453 22 p. Research output: Contribution to journal › Article › peer-review |
Wang, G., , Delaspre, F., Walker, S. L., White, D. T., Ceasrine, A., Kuruvilla, R., Li, R.-J., Shim, J. S., Liu, J. O., Parsons, M. J. & Mumm, J. S., 2015, In: eLife. 4 Research output: Contribution to journal › Article › peer-review |
Urban, B. E., Neogi, P., Senthilkumar, K., , Jagadeeshwaran, P., Kim, S., Fujita, Y. & Neogi, A., 2012, In: Selected Topics in Quantum Electronics, IEEE Journal of. 18, 4, p. 1451-1456 6 p. Research output: Contribution to journal › Article › peer-review |
Jagadeeswaran, P., Carrillo, M., Radhakrishnan, U. P., & Kim, S., 2011, In: Methods in Cell Biology. 101, p. 197-203 7 p. Research output: Contribution to journal › Article › peer-review |
Jagadeeswaran, P., Radhakrishnan, U. P., Kim, S., , Xie, D. & Hsieh, J.-T., 2011, In: Cancer Research. 71, 8 Supplement, p. 4377-4377 1 p. Research output: Contribution to journal › Article › peer-review |
Carrillo, M., Kim, S., , Kulkarni, V. & Jagadeeswaran, P., Dec 15 2010, In: Blood Cells, Molecules, and Diseases. 45, 4, p. 326-33 8 p. Research output: Contribution to journal › Article › peer-review |
Kim, S., Radhakrishnan, U. P., , Kulkarni, V. & Jagadeeswaran, P., Mar 15 2010, In: Blood Cells, Molecules, and Diseases. 44, 3, p. 169-74 6 p. Research output: Contribution to journal › Article › peer-review |
Kim, S., Carlson, R., Zafreen, L., & Jagadeeswaran, P., Sep 2009, In: Zebrafish. 6, 3, p. 269-74 6 p. Research output: Contribution to journal › Article › peer-review |
, Pendse, A., Barjatiya, M. & Singh, P., 1996, In: Urolithiasis. p. 450 Research output: Contribution to journal › Article › peer-review |
Singh, P. P., Pendse, A. K., Ahmed, A., Ramavataram, D. V. & , 1995, In: Urological Research. 23, 3, p. 201-3 3 p. Research output: Contribution to journal › Article › peer-review |
, Pendse, A., Ahmed, A. & Singh, P., 1992, In: Indian Journal of Clinical Biochemistry. 7, 2, p. 205-206 2 p. Research output: Contribution to journal › Article › peer-review |
Ahmed, A., Pendse, A., & Singh, P., 1992, In: Indian Journal of Clinical Biochemistry. 7, 2, p. 171-178 8 p. Research output: Contribution to journal › Article › peer-review |
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Research Team
Antara Chaudhary
- Medical Scholar
- (2025-2029)
Sreeja Sappati
- Medical Scholar
- (2026-2030)
Timothy Pham
- Medical Scholar
- (2026-2030)
Shristhi Desai
- Undergraduate Honors Program Research
- (2025-2028)
Keyana Williams
- Undergraduate Honors Program Research
- (2024-2027)
Sai Nasavally
- Undergraduate Honors Program Research
- (2023-2026)
Sreeja Sappati
- CURS Students
- (2024-2026)
Timothy Pham
- CURS Students
- (2024-2026)
Shrusthi Desai
- CURS Students
- (2025-2029)
Hemala Kupusmay
- CURS Students
- (2024-2028)
Research Team Alumni
Survarsha Sura
- (2019-2021)
Anabelle O’keefe
- (2019-2022)
Katherine McCartney
- (2019-2022)
Rohan Kapuria
- (2020-2021)
Chelsea Appiah
- (2020-2023)
Aminah Wood
- (2022-2023)
Kunal Hotwani
- (2021-2023)
Raymond Chen
- (2022-2023)
Vaani Balyan
- (2022-2024)
Keshu Bhat
- (2022-2024)
Aiden Van Derhei
- (2022-2024)
Umasai Kandepu
May Ye Mon
Karen Aikhionbare
Logan Ouellette