The Moskophidis Laboratory
Dimitrios Moskofidis, PhD, MD
(Demetrius Moskophidis)
Professor
Biochemistry & Molecular Biology
& Graduate Studies
Member, Molecular Oncology & Biomarkers Program
Chaperone Biology & Metabolism Research Group
Jump to: Research SummaryImpact on Georgia patientsResearch Focus Research Interests Publications
Contact Us
The Dimitrios Moskophidis Lab
Health Sciences Campus
1410 Laney-Walker Blvd., CN-3156D1
(706) 721-8738
Research Summary
The scope of our research includes studies on immune regulation, microbial (viral) pathogenesis and inflammation as well as studies on protein homeostasis and molecular chaperone biology/function. These are areas of great medical importance and there is reasonable expectation that this research will continue to provide the rationale to develop novel strategies to prevent, and perhaps more effectively treat, viral infectious diseases as well as patients with cancer and with age-related neurodegenerative diseases.
Impact on Patients in Georgia
Dr. Moskofidis made foundational discoveries in the 1990s that changed our understanding of how the immune system regulates its response to persistent infections—including the phenomenon of T cell exhaustion, a concept that became central to the entire field of cancer immunotherapy.
His current work on molecular chaperones (heat shock proteins) reveals how tumors hijack cellular stress-response machinery to fuel their growth and protect themselves from treatment.
Working in close collaboration with Dr. Mivechi, his lab has demonstrated that blocking key heat shock proteins can halt the development of liver cancer, breast cancer, and leukemia—findings with direct relevance to Georgia's elevated rates of these diseases.
Research Focus
The primary focus of research in my laboratory, over the past two decades, has been to investigate microbial (viral) pathogenesis and immunology/inflammation, as well as mechanisms of protein homeostasis and molecular chaperone biology. The specific research areas can be summarized as follows:
- Function of molecular chaperones and heat shock transcription factors in mouse models of human diseases (cancer).
- Deciphering the fundamental mechanisms coordinating the immune response to acute versus persistent viral infections and the implications in cancer immune evasion.
View Pure Research Profile
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, , Pandya, B., Pang, J., Fernandez, D., Eroglu, B., & , Jun 1 2026, In: The Journal of cell biology. 225, 6 Research output: Contribution to journal › Article › peer-review |
Bhatt, B., Kumar, K., , Ganesan, D., Anazodo, F., Rathakrishnan, A., Zhu, H., Wanna, A., Jiang, C., Jayavelu, T., , , , Sheridan, B. S., , & , Mar 1 2025, In: Journal of immunology (Baltimore, Md. : 1950). 214, 3, p. 446-459 14 p. Research output: Contribution to journal › Article › peer-review |
, & , 2023, Methods in Molecular Biology. Humana Press Inc., p. 81-94 14 p. (Methods in Molecular Biology; vol. 2693). Research output: Chapter in Book/Report/Conference proceeding › Chapter |
Eroglu, B., , Deane, S., Öztürk, B., Ross, O. A., & , Apr 2022, In: Cellular and Molecular Life Sciences. 79, 4, 198. Research output: Contribution to journal › Article › peer-review |
Eroglu, B., Pang, J., , , & , 2020, In: Molecular Cancer Research. 18, 3, p. 463-476 14 p. Research output: Contribution to journal › Article › peer-review |
Cho, W., , Pang, J., Wang, Y., & , May 1 2019, In: Molecular and Cellular Biology. 39, 9, e00391-18. Research output: Contribution to journal › Article › peer-review |
, Qiao, A., & Mivechia, N. F., Sep 1 2018, In: Molecular and Cellular Biology. 38, 18, e00095-18. Research output: Contribution to journal › Article › peer-review |
, Eroglu, B., & , 2018, Methods in Molecular Biology. Humana Press Inc., p. 1-22 22 p. (Methods in Molecular Biology; vol. 1709). Research output: Chapter in Book/Report/Conference proceeding › Chapter |
Qiao, A., , Pang, J., & , Mar 6 2017, In: The Journal of cell biology. 216, 3, p. 723-741 19 p. Research output: Contribution to journal › Article › peer-review |
Eroglu, B., Kimbler, D. E., Pang, J., Choi, J., , , & , Sep 2014, In: Journal of Neurochemistry. 130, 5, p. 626-641 16 p. Research output: Contribution to journal › Article › peer-review |
Eroglu, B., Min, J. N., Zhang, Y., Szurek, E., , & , Feb 15 2014, In: Developmental Biology. 386, 2, p. 448-460 13 p. Research output: Contribution to journal › Article › peer-review |
, Hu, Y., Buckhaults, P., & , Oct 12 2012, In: Journal of Biological Chemistry. 287, 42, p. 35646-35657 12 p. Research output: Contribution to journal › Article › peer-review |
, & , Jul 6 2011, In: Cell Metabolism. 14, 1, p. 91-103 13 p. Research output: Contribution to journal › Article › peer-review |
, , Hu, Y., Phillips, A. & , Jun 1 2009, In: Journal of cellular biochemistry. 107, 3, p. 504-515 12 p. Research output: Contribution to journal › Article › peer-review |
Chen, M., Lan, S., Ou, R., Price, G. E., Jiang, H., de la Torre, J. C. & , Jun 2008, In: Journal of General Virology. 89, 6, p. 1421-1433 13 p. Research output: Contribution to journal › Article › peer-review |
Ou, R., Zhang, M., Huang, L., Flavell, R. A., Koni, P. A. & , Mar 2008, In: Journal of Virology. 82, 6, p. 2952-2965 14 p. Research output: Contribution to journal › Article › peer-review |
Wang, G., Ying, Z., , Tu, N., Zhang, Y., Phillips, M., & , Feb 2004, In: Genesis (United States). 38, 2, p. 66-80 15 p. Research output: Contribution to journal › Article › peer-review |
Zhou, S., Ou, R., Huang, L. & , 2002, In: Journal of Virology. 76, 2, p. 829-840 12 p. Research output: Contribution to journal › Article › peer-review |
Koushik, S. V., Wang, J., Rogers, R., , , Creazzo, T. L. & Conway, S. J., May 2001, In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15, 7, p. 1209-1211 3 p. Research output: Contribution to journal › Article › peer-review |
Ou, R., Zhou, S., Huang, L. & , 2001, In: Journal of Virology. 75, 18, p. 8407-8423 17 p. Research output: Contribution to journal › Article › peer-review |
Price, G. E., Gaszewska-Mastarlarz, A. & , 2000, In: Journal of Virology. 74, 9, p. 3996-4003 8 p. Research output: Contribution to journal › Article › peer-review |
& Kioussis, D., Jul 20 1998, In: Journal of Experimental Medicine. 188, 2, p. 223-232 10 p. Research output: Contribution to journal › Article › peer-review |
Tarazona, R., Williams, O., , Smyth, L. A., Tanaka, Y., Murdjeva, M., Wack, A., Mamalaki, C. & Kioussis, D., Jun 1 1998, In: Journal of Immunology. 160, 11, p. 5397-5403 7 p. Research output: Contribution to journal › Article › peer-review |
, Moskophidis, M. & Löhler, J., Feb 1 1997, In: Journal of Immunology. 158, 3, p. 1254-1261 8 p. Research output: Contribution to journal › Article › peer-review |
& Zinkernagel, R. M., Apr 1995, In: Journal of Virology. 69, 4, p. 2187-2193 7 p. Research output: Contribution to journal › Article › peer-review |
, Lechner, F., Hengartner, H. & Zinkernagel, R. M., May 15 1994, In: Journal of Immunology. 152, 10, p. 4976-4983 8 p. Research output: Contribution to journal › Article › peer-review |
, Battegay, M., Bruendler, M. A., Laine, E., Gresser, I. & Zinkernagel, R. M., Mar 1994, In: Journal of Virology. 68, 3, p. 1951-1955 5 p. Research output: Contribution to journal › Article › peer-review |
, Laine, E. & Zinkernagel, R. M., Dec 1993, In: European Journal of Immunology. 23, 12, p. 3306-3311 6 p. Research output: Contribution to journal › Article › peer-review |
Battegay, M., , Waldner, H., Bründler, M. A., Fung-Leung, W. P., Mak, T. W., Hengartner, H. & Zinkernagel, R. M., Nov 15 1993, In: Journal of Immunology. 151, 10, p. 5408-5415 8 p. Research output: Contribution to journal › Article › peer-review |
Zinkernagel, R. M., , Kündig, T., Oehen, S., Pircher, H. & Hengartner, H., Jun 1993, In: Immunological Reviews. 133, 1, p. 199-223 25 p. Research output: Contribution to journal › Article › peer-review |
, Lechner, F., Pircher, H. & Zinkernagel, R. M., 1993, In: Nature. 362, 6422, p. 758-761 4 p. Research output: Contribution to journal › Article › peer-review |
, Lechner, F., Plrcher, H. & Zinkernagel, R. M., 1993, In: Nature. 364, 6434, p. 262 1 p. Research output: Contribution to journal › Comment/debate › peer-review |
Althage, A., Odermatt, B., , Kündig, T., Hengartner, U. H. H. & Zinkernagel, R. M., Jul 1992, In: European Journal of Immunology. 22, 7, p. 1803-1812 10 p. Research output: Contribution to journal › Article › peer-review |
, Pircher, H., Ciernik, I., Odermatt, B., Hengartner, H. & Zinkernagel, R. M., Jun 1992, In: Journal of Virology. 66, 6, p. 3661-3668 8 p. Research output: Contribution to journal › Article › peer-review |
Aebischer, T., , Rohrer, U. H., Zinkernagel, R. M. & Hengartner, H., 1991, In: Proceedings of the National Academy of Sciences of the United States of America. 88, 24, p. 11047-11051 5 p. Research output: Contribution to journal › Article › peer-review |
Pircher, H., Rohrer, U. H., , Zinkernagel, R. M. & Hengartner, H., 1991, In: Nature. 351, 6326, p. 482-485 4 p. Research output: Contribution to journal › Article › peer-review |
, Frei, K., Löhler, J., Fontana, A. & Zinkernagel, R. M., 1991, In: Journal of Virology. 65, 3, p. 1364-1369 6 p. Research output: Contribution to journal › Article › peer-review |
, Fang, L., Gossmann, J., Drjupin, R., Löhler, J., Bruns, M. & Lehmann-Grube, F., Mar 1 1990, In: Journal of Immunology. 144, 5, p. 1926-1934 9 p. Research output: Contribution to journal › Article › peer-review |
Pircher, H., , Rohrer, U., Bürki, K., Hengartner, H. & Zinkernagel, R. M., 1990, In: Nature. 346, 6285, p. 629-633 5 p. Research output: Contribution to journal › Article › peer-review |
Gessner, A., & Lehmann-Grube, F., Jan 1 1989, In: Journal of Immunology. 142, 4, p. 1293-1298 6 p. Research output: Contribution to journal › Article › peer-review |
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Research Team
Peter Biggs